Words of wisdom. Re: Identification of patients with prostate cancer who benefit from immediate postoperative radiotherapy: EORTC 22911.
نویسنده
چکیده
In EORTC22911, 1005 patients with pT3 prostate cancer following radical prostatectomy were randomized to observation or immediate postoperative adjuvant radiotherapy [1]. Van der Kwast performed a pathologic analysis of EORTC22911 using the radical prostatectomy specimens from 552 study patients. Patients with negative surgical margins had no benefit from postoperative radiotherapy. However, with positive margins, the hazard ratio for prostate-specific antigen (PSA) relapse was 0.38 for those receiving radiation compared with those who did not. Adjuvant radiation would prevent biochemical relapse by year 5 in 291 of every 1000 patients with positive margins compared with 88 of 1000 patients with negative margins.
منابع مشابه
Reply from Authors re: Ronald C. Chen. Making Individualized Decisions in the Midst of Uncertainties: The Case of Prostate Cancer and Biochemical Recurrence. Eur Urol 2013;64:916–8: Optimal Timing for Postoperative Radiation: Still an Unanswered Question
[2] Trock BJ, Han M, Freedland SJ, et al. Prostate cancer-specific survival following salvage radiotherapy vs observation in men with biochemical recurrence after radical prostatectomy. JAMA2008;299: 2760–9. [3] Stephenson AJ, Shariat SF, Zelefsky MJ, et al. Salvage radiotherapy for recurrent prostate cancer after radical prostatectomy. JAMA 2004; 291:1325–32. [4] Thompson IM, Tangen CM, Parade...
متن کاملWords of wisdom. Re: Postoperative radiotherapy after radical prostatectomy for high-risk prostate cancer: long-term results of a randomised controlled trial (EORTC trial 22911).
BACKGROUND We report the long-term results of a trial of immediate postoperative irradiation versus a wait-and-see policy in patients with prostate cancer extending beyond the prostate, to confirm whether previously reported progression-free survival was sustained. METHODS This randomised, phase 3, controlled trial recruited patients aged 75 years or younger with untreated cT0-3 prostate canc...
متن کاملOutcomes for radiation therapy after radical prostatectomy for prostate cancer: what really matters?
This comment should start with the acknowledgement that we are firm advocates of the value of radiotherapy (RT) after radical prostatectomy (RP) in many patients with prostate cancer. However, we are concerned that a published and recently presented study (European Organization for Research and Treatment of Cancer, EORTC, Trial 22911) by Bolla et al. [1,2], of adjuvant RT vs observation for pat...
متن کاملPostoperative radiotherapy after radical prostatectomy: a randomised controlled trial (EORTC trial 22911).
BACKGROUND Local failure after prostatectomy can arise in patients with cancer extending beyond the capsule. We did a randomised controlled trial to compare radical prostatectomy followed by immediate external irradiation with prostatectomy alone for patients with positive surgical margin or pT3 prostate cancer. METHODS After undergoing radical retropubic prostatectomy, 503 patients were rand...
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ورودعنوان ژورنال:
- European urology
دوره 53 3 شماره
صفحات -
تاریخ انتشار 2007