Words of wisdom. Re: Identification of patients with prostate cancer who benefit from immediate postoperative radiotherapy: EORTC 22911.

نویسنده

  • Markus Graefen
چکیده

In EORTC22911, 1005 patients with pT3 prostate cancer following radical prostatectomy were randomized to observation or immediate postoperative adjuvant radiotherapy [1]. Van der Kwast performed a pathologic analysis of EORTC22911 using the radical prostatectomy specimens from 552 study patients. Patients with negative surgical margins had no benefit from postoperative radiotherapy. However, with positive margins, the hazard ratio for prostate-specific antigen (PSA) relapse was 0.38 for those receiving radiation compared with those who did not. Adjuvant radiation would prevent biochemical relapse by year 5 in 291 of every 1000 patients with positive margins compared with 88 of 1000 patients with negative margins.

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منابع مشابه

Reply from Authors re: Ronald C. Chen. Making Individualized Decisions in the Midst of Uncertainties: The Case of Prostate Cancer and Biochemical Recurrence. Eur Urol 2013;64:916–8: Optimal Timing for Postoperative Radiation: Still an Unanswered Question

[2] Trock BJ, Han M, Freedland SJ, et al. Prostate cancer-specific survival following salvage radiotherapy vs observation in men with biochemical recurrence after radical prostatectomy. JAMA2008;299: 2760–9. [3] Stephenson AJ, Shariat SF, Zelefsky MJ, et al. Salvage radiotherapy for recurrent prostate cancer after radical prostatectomy. JAMA 2004; 291:1325–32. [4] Thompson IM, Tangen CM, Parade...

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Words of wisdom. Re: Postoperative radiotherapy after radical prostatectomy for high-risk prostate cancer: long-term results of a randomised controlled trial (EORTC trial 22911).

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Outcomes for radiation therapy after radical prostatectomy for prostate cancer: what really matters?

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Postoperative radiotherapy after radical prostatectomy: a randomised controlled trial (EORTC trial 22911).

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عنوان ژورنال:
  • European urology

دوره 53 3  شماره 

صفحات  -

تاریخ انتشار 2007